Center for Infectious Disease and Vector Research

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CIDVR Seminar Speaker Dr. Jake Tu December 9, 2016 @ 10:00am

Friday, December 9, 2016
1011 a.m.


Life Sciences
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Dear Faculty, Postdocs, Students, and Friends:

You are cordially invited to attend an IIGB Seminar presented by 


Jake Tu


Department of Biochemistry

Virginia Tech, Blacksburg, VA




“Sex and the control of mosquito-borne infectious diseases”


 DATE:  December 9, 2016

 LOCATION: Life Science Psychology 2550

TIME: 10:00 AM


Host: Dr. Sarjeet Gill  


Sex is critical to the survival and evolution of many organisms including mosquitoes. Only female mosquitoes feed on blood and transmit disease-causing parasites or viruses while the non-biting males are harmless in this context. Sex is determined by at least two types of sex chromosome karyotypes in mosquitoes: the well-differentiated or heteromorphic X and Y sex chromosomes in Anopheles and the homomorphic sex chromosomes in Aedes and Culex mosquitoes. Genetic evidence suggests that a dominant male-determining factor (M factor) from the male-specific sex-determining chromosome provides the primary signal that initiates male development and controls sex determination in mosquitoes. Mosquitoes that lack the M factor develop into the default female sex.  We have recently discovered a male determining factor Nix in Aedes aegypti and a strong M factor candidate Guy1 in Anopheles stephensi mosquitoes. In this presentation, I will discuss evidence that supports Nix and Guy1 as the M factors in these two divergent mosquito species. I will also compare and contrast the outcome of ectopic expression of Nix and Guy1 inAedes and Anopheles mosquitoes in the context of the need for dosage compensation. I will also discuss our efforts to bias mosquito sex ratio towards the harmless males for the control of mosquito-borne infectious diseases such as malaria, dengue, and Zika.

Additional Information:

Open to:

General Public




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