Center for Infectious Disease and Vector Research

Events Calendar

IIGB Sponsored Lunch Seminar-Sven Bocklandt, Ph.D., BioNano Genomics

Wednesday, July 22, 2015
11 a.m.1 p.m.


Genomics Building
Parking Information


IIGB Sponsored Lunch Seminar


Illuminating the Dark Matter:

De Novo Assembly and Mapping of the Structural Variation of the Genome


Sven Bocklandt, Ph.D., BioNano Genomics

Wednesday, July 22 2015

11:00 AM – 12:00 PM

Lunch will be served afterwards

Please RSVP: gencore@ucr.edu

Genomics Building Room 1102A

The majority of complex genomes is made up of repetitive and regulatory elements, yet our

current analysis of the genome focuses on single nucleotide changes and exome sequencing.

The “Dark Matter” that controls most of our genome is largely ignored, because short read

sequencing is unable to map these highly repetitive sequences.


BioNano Genomics’ Irys instruments uses nanochannel arrays to linearize and image

megabase size single DNA molecules. This extremely long read data can elucidate genomewide

complex structural variation like balanced/unbalanced translocations, inversions, and

large indels. Our de novo genome maps can identify and phase CNVs, resolve complex

repetitive regions, scaffold short and long-read NGS contigs to create better-than-reference

assemblies, and resolve complex repetitive regions.


Applications range from bacterial engineering to building reference genomes for complex

polyploid plants all the way to clinical use. We will touch on long range phasing of

methylation patterns, and analysis of chromatin structure.

Additional Information:

Open to:

General Public




Institute for Integrative Genome Biology

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

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Institute of Integrative Genomics Biology
2150 Batchelor Hall

Tel: (951) 827-7177