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Center for Infectious Disease and Vector Research



Events Calendar


Seminar:
CEPCEB Seminars BPSC 252

Steve Kay

Friday, April 26, 2013
Noon1 p.m.

Location:

Genomics Building , Genomics Auditorium RM 1102A
Parking Information

Description:

Steve Kay
Dean of Dornsife College of Letters, Arts and Sciences
University of Southern California

 Title:

“Large Scale Discovery Approaches to Understanding Circadian Networks”


DATE:04/26/13

 LOCATION: Genomics Auditorium, RM 1102A

Time:12:10pm

Host: Julia Bailey-Serres   

 

Abstract:

 

Our laboratory studies the composition and architecture of circadian networks in plants and animals. These networks are thought to provide adaptive advantages to organisms, and are now known to be pervasive in their integration with many other regulatory modules in multiple cell types. We employ high throughput genomic and chemical biology pipelines to identify network components and apply mechanistic approaches to understand their detailed function and interactions.  In both plant and animal systems we have found that circadian networks are hierarchical and composed of regulatory layers that act at the transcriptional and posttranscriptional levels. Increasingly we are finding that circadian regulation is tightly integrated with metabolic networks, and operate with reciprocal regulatory interactions.

 

Recent results are leading us to understand how clocks regulate processes such as glucose homeostasis in mammals and growth in plants. Our data reveals the identification of the first proof of concept chemical probes for the manipulation of circadian clocks by small molecules. Target deconvolution of these chemical probes is revealing novel features of clock function. As we continue computational approaches to mine existing data collections for comprehensive network reconstruction, more is understood how such approaches present circadian clocks as highly interesting targets for development of novel therapeutics and agricultural biotechnology products.

 

Additional Information:

Open to:

General Public

Admission:

Free

Sponsor:

Institute for Integrative Genome Biology


More Information

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University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

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Institute of Integrative Genomics Biology
2150 Batchelor Hall

Tel: (951) 827-7177

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